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The Tabin Lab

The laboratory studies the genetic basis by which form and structure are regulated, both during embryonic development to produce the exquisite morphology of the vertebrate embryo and over evolutionary time to generate the extraordinary and beautiful diversity of animal forms on this planet. In our developmental studies we combine classical methods of experimental embryology with modern molecular, imaging, genetic and genomic techniques for interrogating and testing gene function. In our evolutionary work we have addressed question of morphological, behavioral and metabolic evolution in a variety of species using both developmental and genetic approaches.

  • Eggs after manipulation in the incubating room (Tabin lab)
  • Skeletal prep of Mouse phalanges
  • Fish pigmentation (Nicolas Rohner)
  • Skeletal preparation between Surface fish and cavefish (Nicolas Rohner)
  • development - Shh in situ 4 days (Matt Schwarz)
  • Limb bud electroporated with GFP expression construct, 3.5 days (Matt Schwarz)
  • neural tube Isl1&2_FoxP1_Hb9 (Patrick Tschopp)
  • Acvr2a noncoding element expression pattern (Nicolas Rohner)
  • House Snake embryo (Patrick Tschopp)
  • Luminal surface of developing chick intestine (Tyler Huycke)
  • Single molecule FISH (Shh) (Tyler Huycke)
  • Innervation in the developing limb (Patrick Tschopp)
  • Joint-specific expression of transcription factor Gdf5 (Patrick Tschopp)
  • E12 small intestine of chick (Tyler Huycke)
  • Skeletal preparation between Surface fish and cavefish (Nicolas Rohner)
  • Chimp skeleton (Museum of Natural History in New York)
  • Fish pigmentation (Nicolas Rohner)
  • Fish pigmentation (Nicolas Rohner)
  • 12 day chick wing skeleton (Matt Schwarz)
  • 12 day chick skeleton (Matt Schwarz)
  • E12 esophagus luminal structure of chick (Tyler Huycke)
  • Python embryo (Patrick Tschopp)

Limb development and skeletal morphogenesis

The vertebrate limb is a classical model for understanding patterning and morphogenesis of the embryo. We have a variety of projects using both the chick and mouse systems to address a range of questions, [...]

Physical forces in gut development

There is an increasing appreciation for the role of physical forces in orchestrating aspects of development. We have been focusing on the chick midgut, where we have uncovered roles for physical forces in coiling as well as in villus formation and stem cell localization. Current efforts address [...]

Cave fish evolution & evolution of human-specific traits

One of the evolutionary systems we currently use involves the comparison of fish adapted to life in caves with their free-swimming river cousins, with whom they are still inter-fertile. [...]

We are investigating the genetic basis for a number of human-specific characters, including our unusual skin (miniaturized hair follicles and expansive sweat glands which together allow efficient theromoregulation through perspiring), [...]

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